Do You Really Need an Anti-Inflammatory Supplement?
Your Guide to 2023’s Top Anti-Inflammation Supplements
Chronic inflammation is at the root of some of the most debilitating and life-threatening diseases facing our population today. Research even suggests a strong correlation between inflammation-related diseases and 50% of all deaths.1
With mounting evidence uncovering the severity of chronic inflammation, it makes sense that more medical experts and patients alike are exploring more ways to prevent, manage, and, even, reverse chronic inflammation before it’s too late.
What is inflammation?
Inflammation is one of our most vital functions. Without inflammation we could not properly fight off infections and heal from injuries. But, like every process in the body, balance is necessary. When inflammation persists after an initial threat has passed, the very defense mechanism that was working for the body turns against it and chronic inflammation is the result of those powers going unchecked.
The effects of chronic inflammation can impact almost every system in the body—digestive, neurological, musculoskeletal, hormonal. But despite its far reach, chronic inflammation is surprisingly tricky to spot in advance.
Over 60% of Americans live with at least one chronic condition, and that number is expected to rise incrementally over the next 30 years.2 To combat the prevalence of chronic inflammation, interest in preventative measures—or, even, solutions that can reverse damage from inflammation—is at an all-time high.
The wellness industry has already responded to this relatively new consumer awareness; today the wellness market is saturated with products targeting inflammation. To help you navigate the pharmacy aisles more proficiently, we’ve compiled a list of reputable anti-inflammation solutions. But before we dive into anti-inflammatory product recommendations, we need to dig a little deeper to understand the process and conditional products of chronic inflammation, as well as the ingredients proven to offset it.
What causes inflammation?
Diet
Diet is one of the biggest instigators of chronic inflammation and can spark the onset of chronic conditions like obesity, type 2 diabetes, joint pain, and heart disease. According to studies, dietary habits that are high in refined starches, sugars, saturated and trans-fatty acids can trigger the body to produce more pro-inflammatory cytokines (small proteins that influence immune system responses).3 Further, diets filled with pro-inflammatory ingredients are generally lower in vital anti-inflammatory ingredients. Focusing eating patterns around omega-3 fatty acids, whole grains, and antioxidant-rich fruits and vegetables have been shown to reduce inflammation and chronic disease.
Stress and depression
Managing stress is not just vital for our emotional wellbeing, but also for our long-term physical health. Research has long suggested an almost-cyclical relationship between stress and depression, and chronic inflammation. Experiencing ongoing stress can cause endocrine and immune system dysfunction, subsequently triggering low-grade inflammation and activating further development of depression.4 Our bodies are not built to withstand unrelenting stress. But unfortunately, modern lifestyle precipitates greater stress.
Exposure to environmental toxins
Our external environments play a huge role in shaping our internal health. Research reveals that the presence of chemicals in the air, or water or food supply spur inflammation.5 When our bodies sense external threats, including the presence of inorganic chemicals, it increases the production of proinflammatory cytokines to fend off the threat. And constant exposure activates a steady uptick of cytokines, naturally leading to chronic inflammation. Certain chemicals known as endocrine disruptors (including chemicals found in plastics and pesticides) have also been shown to alter the microbiome in our gut, leading to further stress and inflammation.6
Untreated infection
When the body senses the threat of a potential infection, it releases an inflammatory counter-attack to protect our tissues and organs.
This response is only meant to be temporary, but sometimes the inflammatory response lingers for too long, prompting white blood cells to turn on the body and begin attacking healthy cells and tissue.
When will you see results?
Everybody responds to new supplements differently. When you begin to incorporate new ingredients into your daily life, the timeline of their impact may be influenced by a few factors, including: age, lifestyle, current symptoms, medical history, and consistency.
After incorporating anti-inflammation supplements with clinically-proven ingredients into your daily life, you may notice the following improvements around the 60 and 90 day marks.
60 Days
By the 60 day mark, you may notice less joint pain and faster recovery time after a strenuous workout.
90 Days
By the 90 day mark, you may notice improvements in your joint mobility and more stable blood-sugar levels.
Why are anti-inflammatory ingredients important?
Supplementing your daily diet with ingredients that have been proven to decrease inflammation, can not only increase your quality of life in the short-term by improving mobility and reducing pain, but can also strengthen your defenses against chronic diseases like arthritis, diabetes, cardiovascular disease, and Alzheimer’s.
A reduced and more easily-absorbed form of curcumin.
Tetrohydrocurcumin is increasingly regarded for its potent response to inflammatory conditions, and ability to enhance insulin sensitivity and reduce inflammation-induced tissue damage.
Tetrohydrocurcumin counters inflammation by eliminating reactive oxygen species and suppressing pro-inflammatory proteins that bind genes to DNA.7,8 Tetrohydrocurcumin is noted for its protection against pro-inflammatory diseases like cardiovascular disease, autoimmune diseases, depression, and more.
Tetrohydrocurcumin is increasingly regarded for its potent response to inflammatory conditions, and ability to enhance insulin sensitivity and reduce inflammation-induced tissue damage.
Tetrohydrocurcumin counters inflammation by eliminating reactive oxygen species and suppressing pro-inflammatory proteins that bind genes to DNA.7,8 Tetrohydrocurcumin is noted for its protection against pro-inflammatory diseases like cardiovascular disease, autoimmune diseases, depression, and more.
A naturally occurring substance that accumulates in injured tissues in response to increased oxidative damage.9,10 The supplementation of Ergothioneine can reduce cellular inflammation by stopping processes that prevent the mitochondria, or the energy centers of our cells, from producing adequate energy levels. Ergothioneine is suggested to support the prevention of cardiovascular disease, chronic pain, and Alzheimer’s disease.
A naturally occurring molecule found in some plants that suppresses the activation of pro-inflammatory molecules.11,12 Research also indicates Dihydroberberine can reduce the build-up of fats, cholesterol and other substances in and on the artery walls, which have a strong correlation with cardiac emergencies. The anti-inflammatory potential of dihydroberberine may be useful in preventing the development of chronic inflammatory conditions including artery build-up and blood clots, ulcers, osteoarthritis, cancer, and diabetes.
A powerful anti-inflammatory, plant-derived chemical that blocks proinflammatory molecules. trans-Resveratrol restores cognitive impairment and extends longevity by supporting anti-aging enzymes.13, 14
With its potent anti-inflammatory properties, ginger root can reduce symptoms of arthritis. By suppressing pro-inflammatory molecules, ginger root protects the body from the onset of inflammation-induced conditions like diabetes, arthritis, Crohn’s disease, and more.15,16
Vitamin B12 offers a range of supplementary benefits, including enhancing energy and reducing pain. Vitamin B12 supplementation can significantly reduce pain and has been shown to reduce local inflammation following tissue injuries.17,18
Supplement checklist
Here are the qualities you should look for when shopping for supplements:
Bioavailability refers to how easy it is for your body to absorb ingredients.
For example, tetrohydrocurcumin is a more bio-available formulation of curcumin. Supplementing with ingredients that are easier to absorb and metabolize means that the benefits—like inflammation reduction and cellular protection—are more potent.
For example, tetrohydrocurcumin is a more bio-available formulation of curcumin. Supplementing with ingredients that are easier to absorb and metabolize means that the benefits—like inflammation reduction and cellular protection—are more potent.
Formulation under the guidance of doctors fosters efficacy.
From working with patients everyday, Doctors have a profound understanding of what causes inflammation—and how to fight it.
Ingredients vetted by multiple studies promote efficacy and safety.
Not every supplement is created equal. Looking for ingredients that have been verified by clinical research is the most assured way to distinguish worthy supplements.
| Root by Hudson™ AIM-01™ |
Ibuprofen (Advil) |
Natural Force’s Pure Omega-3 |
Thorne’s Berberine |
NOW Foods Astaxanthin |
|
| Pain reduction | • | ||||
| Joint improvement | • | • | |||
| Brain Health | • | ||||
| Insulin Regulation | • | ||||
| Antioxidant support | • |
AIM-01
AIM-01 was designed by doctors to reduce inflammation and enhance longevity. Root is formulated with plant-based, clinically-proven bioavailable ingredients to defend the body against joint pain and improve insulin sensitivity and joint mobility. As of now, AIM-01 is only available for purchase online and at Hudson Health’s New York City locations.
Pros
Multi-targeted anti-inflammation
Plant-based ingredients
Formulated by doctors
Bioavailable ingredients
Cons
Sold only online and at
Hudson Medical
Not available internationally
Ibuprofen (Advil)
As a widely available OTC drug, Ibuprofen is one of the most common supplements people reach for to diminish pain and fevers. Too much dependence on Ibuprofen may result in ulcers, sub-optimal kidney function, and GI issues.
Pros
Widespread OTC availability
Low-cost
Available in multiple forms (tablets, chewable tablets)
Cons
Some studies suggest long-term use may worsen joint inflammation
Natural Force’s Pure Omega-3
Natural Force’s Pure Omega-3 addresses one of the most common detractors of Omega-3 oil: fishy taste and fish burps. Their lemon flavoring makes this supplement more palatable. It is also manufactured and tested to ensure no mercury traces.
Pros
Bio-available
Lemon-flavored
UV light-blocking bottle
Mercury-free
Sustainably-sourced from
wild-caught fish
Paleo Paleo friendly
Cons
Only available in liquid form
Berberine
This supplement offers plant-based support for heart health, immunity, GI health, and weight management. It can be purchased in tandem with the company’s wide-range of vetted, targeted supplements, as well as personalized recommendations and health tests.
Pros
Plant-based
Multi-targeting (supports heart health, immunity, and
GI health)
Cons
Studies show Berberine is
less bioavailable than Dihydroberberine19
NOW Foods Astaxanthin
This softgel formulation offers cellular protection. In addition to Astaxanthin, it also contains vitamin E to bolster antioxidant support. It is available across multiple retailers.
Pros
Multi-targeting
(supports joint, eye, brain, and immune health)
Pricing
Cons
Contains refined soy oil
(non GMO)
Manufactured in a facility that processes other ingredients containing common allergens, like wheat, gluten, milk, egg,
and shellfish.
- Furman, D., Campisi, J., Verdin, E. et al. Chronic inflammation in the etiology of disease across the life span. Nat Med 25, 1822–1832 (2019). https://doi.org/10.1038/s41591-019-0675-0
- Pahwa R, Goyal A, Jialal I. Chronic Inflammation. [Updated 2022 Jun 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/
- Dario Giugliano, Antonio Ceriello, Katherine Esposito,
- The Effects of Diet on Inflammation: Emphasis on the Metabolic Syndrome, Journal of the American College of Cardiology, Volume 48, Issue 4, 2006, Pages 677-685, ISSN 0735-1097, https://doi.org/10.1016/j.jacc.2006.03.052.
- Maydych V. The Interplay Between Stress, Inflammation, and Emotional Attention: Relevance for Depression. Front Neurosci. 2019 Apr 24;13:384. doi: 10.3389/fnins.2019.00384. PMID: 31068783; PMCID: PMC6491771.
- Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, Nadal A, Palanza P, Panzica G, Sargis R, Vandenberg LN, Vom Saal F. Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017 Mar;68:3-33. doi: 10.1016/j.reprotox.2016.10.001. Epub 2016 Oct 17. PMID: 27760374; PMCID: PMC5365353.
- Gálvez-Ontiveros Y, Páez S, Monteagudo C, Rivas A. Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases. Nutrients. 2020 Apr 21;12(4):1158. doi: 10.3390/nu12041158. PMID: 32326280; PMCID: PMC7231259.
- Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected] [published correction appears in J Biol Chem 1995 Dec 15;270(50):30235]. J Biol Chem. 1995;270(42):24995-25000. doi:10.1074/jbc.270.42.24995
- Nakamura Y, Ohto Y, Murakami A, Osawa T, Ohigashi H. Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo. Jpn J Cancer Res. 1998;89(4):361-370. doi:10.1111/j.1349-7006.1998.tb00572.x
- “What Are Common Symptoms of Autoimmune Disease?” Johns Hopkins Medicine, 22 July 2022, https://www.hopkinsmedicine.org/health/wellness-and-prevention/what-are-common-symptoms-of-autoimmune-disease#:~:text=Autoimmune%20Disease%20Basics,wide%20range%20of%20body%20parts”
- Edwin McDonald, MD. “Foods That Cause Inflammation & How to Reduce Inflammation.” Foods That Cause Inflammation & How to Reduce Inflammation – UChicago Medicine, UChicago Medicine, 4 Sept. 2020, https://www.uchicagomedicine.org/forefront/gastrointestinal-articles/what-foods-cause-or-reduce-inflammation#:~:text=All%20processed%20foods%20can%20cause,that%20leads%20to%20chronic%20inflammation”>https://www.uchicagomedicine.org/forefront/gastrointestinal-articles/what-foods-cause-or-reduce-inflammation#:~:text=All%20processed%20foods%20can%20cause,that%20leads%20to%20chronic%20inflammation
- 11.Dai B, Ma Y, Wang W, et al. Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators. J Cell Mol Med. 2017;21(10):2573-2585. doi:10.1111/jcmm.13178
- 12.Xu L, Lin G, Yu Q, et al. Anti-Hyperuricemic and Nephroprotective Effects of Dihydroberberine in Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice. Front Pharmacol. 2021;12:645879. Published 2021 Apr 20. doi:10.3389/fphar.2021.645879
- Li J, Zhang CX, Liu YM, Chen KL, Chen G. A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Oncotarget. 2017;8(39):65717-65729. Published 2017 Aug 9. doi:10.18632/oncotarget.20084
- Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91. Published 2018 Sep 9. doi:10.3390/biomedicines6030091
- Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006;71(10):1397-1421. doi:10.1016/j.bcp.2006.02.009
- Habib SH, Makpol S, Abdul Hamid NA, Das S, Ngah WZ, Yusof YA. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (Sao Paulo). 2008;63(6):807-813.
- Hosseinzadeh H, Moallem SA, Moshiri M, Sarnavazi MS, Etemad L. Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice. Arzneimittelforschung. 2012;62(7):324-329. doi:10.1055/s-0032-1311635
- Ehmedah A, Nedeljkovic P, Dacic S, et al. Vitamin B Complex Treatment Attenuates Local Inflammation after Peripheral Nerve Injury. Molecules. 2019;24(24):4615.
- Moon JM, Ratliff KM, Hagele AM, Stecker RA, Mumford PW, Kerksick CM. Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial. Nutrients. 2021 Dec 28;14(1):124. doi: 10.3390/nu14010124. PMID: 35010998; PMCID: PMC8746601.